[Nettime-bold] lab[wh]or[e]atory [datah!bleedin 1.1]

["data[h!]bleede" <mezandwalt@wollongong.starway.net.au>]

_Testing for skin corrosion/irritation in laboratory animals has the
potential to cause them discomfort or pain. For this reason,
alternative methods for trying to identify corrosive substances have
been developed. The severity of the skin lesion (i.e. tissue
destruction) lends itself to using non-animal methods that can detect
severe tissue damage. Thus, the feasibility of using non-animal
tests for assessing skin corrosion is probably greater than for trying
to detect toxic effects which are exerted by subtle multifactorial
mechanisms.

As in several other areas of toxicity testing, the evolution of
alternative tests for detecting chemicals which are corrosive to the
skin has resulted in the production of model test systems which
have been designed for a particular market and/or to fulfil a specific
need. The in vitro test systems investigated in this pre-validation
study cover a range of biological complexity: excised rat skin (the
transcutaneous electrical resistance [TER] assay), a
three-dimensional human skin model (Skin2), and a biochemical
matrix (CORROSITEXTM)._

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Testing for skin[ned] corrosi[ve:]on/irritation in lab[wh]or[e]atory
animals has the

alternative methods for trying to identify corrosive sub[conscious]stances
alternative tests for detecting chemicals which are corrosive to the [whore]
As in several other areas of toxicity testing, the evolution of [queendom]
been developed. The severity of the skin[ned whore] lesion (i.e. tizz[y]ue
destruction) lends itself to using non-anim[us]al methods that can detect
have been designed for a particular market and/or to fulfil a specific
matri[cide]x (CORROSI.TEXT.M[other]).

M[other]echanisms

___________________________________________________________




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wollongong.starway.net.au/~mezandwalt






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